Friday, December 14, 2018

REVISION Q.319 - FRAMED FROM WIKIPEDIA



REVISION Q.319 - FRAMED FROM WIKIPEDIA

Q.319 Recently in the news there was a term Superbugs, What is this ?

A) These are the microorganism that are essential for the vital functions of the body

B) These are the enzymes that makes bacteria resistant to broad range of beta-lactam antibiotics

C) These are the bacteria that causes infection which is difficult to treat

D) These are the super weeds that are essential in the treatment of less fertile soils

Ans. C

New Delhi Metallo-beta-lactamase-1 (NDM-1) is an enzyme that makes bacteria resistant to a broad range of beta-lactam antibiotics.
These include the antibiotics of the carbapenem family, which are a mainstay for the treatment of antibiotic-resistant bacterial infections. The gene for NDM-1 is one member of a large gene family that encodes beta-lactamase enzymes called carbapenemases.
Bacteria that produce carbapenemases are often referred to in the news media as "superbugs" because infections caused by them are difficult to treat. Such bacteria are usually susceptible only to polymyxins and tigecycline.
The most common bacteria that make this enzyme are gram-negative such as Escherichia coli and Klebsiella pneumoniae, but the gene for NDM-1 can spread from one strain of bacteria to another by horizontal gene transfer



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